Figure 2.

Genomic organization of aldolase A and C, transgenic constructs, and analysis of transgene expression in transgenic mice. (A) Genomic organization of aldolase A and aldolase C. In situ hybridization probes are indicated below the eighth and ninth exons. Restriction sites: B = BamHI, E = EcoRI, P = PstI, S = SacII, X = XbaI. (B) Transgenic constructs. (C) Reverse transcription–PCR of DNase I-treated RNA isolated from brain (B), liver (L), and muscle (M) of MACZ9 (indicated by 9) and MACZ2Δ9 (2Δ9) mice. Control (Con): tail DNA from a MACZ9 mouse (+) and a nontransgenic littermate (−).