Table 1.

Cytological and histological criteria used for diagnosis of cervical lesions

Lesions	Criteria for diagnosis	Ref.
Cytologic HPV	Koilocytic atypia Multinucleation (frequently binucleation) Dyskeratosis Parakeratosis	34
ASCUS	Nuclear enlargement approximately twice the size of an immature squamous metaplastic cell Slight increase in nucleo-cytoplasmic ratio Nuclear chromatin clumping Variation in nuclear size and shape including mild hyperchromasia, binucleation, and mild irregularity in the nuclear membranes	35, 36
AGCUS	Nuclear enlargement approximately twice the size of an endocervical cell. Nuclear pseudostratification Mild hyperchromasia	37
Discriminating AGUS from neoplastic endocervical cells	Presence of normal ECCs, singly or in sheets Absence of necrosis Absence of papillary groups Mild anisonucleosis Marked chromatin distribution	37
EGD	Nuclei not cytologically malignant Nuclear hyperchromasia and pseudostratification Low mitotic figures Absence of papillary formation and cribriform pattern	38
Histologic HPV	Koilocytic atypia: 4 points Binucleation: 2 points Dyskeratosis: one point Basal cell hyperplasia: one point Papillomatosis: one point Acanthosis: one point	34