TABLE 4.

Estimated Effects of Polymorphisms Selected in Univariable, Multivariable, and Risk Factor-Adjusted Logistic Regression Analyses of PMI

			Univariable*		Multivariable†		Multivariable, Risk Factor-Adjusted‡
Polymorphism		Inheritance Mode	OR [95%CI]	P	OR [95%CI]	P	OR [95%CI]	P	FDR§
IL6	−572G > C	Additive	2.8 [1.27–5.83]	0.0077	2.75 [1.2–6.3]¶	0.017	2.47 [1.02–5.97]e	0.045	+
ICAM1	1462A > G	Additive	1.9 [1.25–2.91]	0.003	1.82 [1.17–2.85]¶	0.009	1.88 [1.17–3.04]¶	0.009	+
SELE	98G > T	Dominant	0.17 [0.03–0.57]	0.0157	0.19 [0.05–0.81]¶	0.025	0.16 [0.03–0.74]¶	0.019	+
CRP	1846 C > T	Dominant	1.89 [1.01–3.7[	0.0519	2.50 [1.27–5.24]||	0.011	2.25 [1.11–4.85] ||	0.03	−
LBP	19983T > C	Dominant	2.28 [1.22–4.21]	0.0089	2.37 [1.23–4.53] ||	0.009	2.81 [1.41–5.65] ||	0.003	−
CAT	−844C > T	Additive	0.67 [0.42–1.04]	0.0830	0.57 [0.37–0.93] ||	0.031	0.55 [0.31–0.93] ||	0.03	−
IL1B	−511T > C	Additive	1.59 [0.93–2.75]	0.0948
	5887C > T	Dominant	0.56 [0.28–1.07]	0.0898
IL6	−597G > A	Additive	0.62 [0.37–1.01]	0.0602
CD14	−260C > T	Dominant	0.56 [0.3–1.08]	0.0754
SELE	561A > C	Dominant	0.10 [0.01–0.46]	0.0231

^*Univariable and †multivariable logistic regression tests for allelic association.

^‡Multivariable logistic regression adjusted for duration of aortic cross-clamping, number of coronary grafts and redo-surgery.

^§False discovery rate controlled at 10% to adjust for multiple comparisons in univariate tests among 48 polymorphisms.

^¶Primary multi-locus genetic model.

^||Alternate multi-locus genetic model.