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. Author manuscript; available in PMC: 2007 Aug 13.
Published in final edited form as: Cancer Cell. 2007 Apr 12;11(5):461–469. doi: 10.1016/j.ccr.2007.02.026

Figure 3.

Figure 3

Short telomeres block tumor formation in a p53 dependent manner. A) Intergenerational breeding scheme. Vertical bars represent telomere lengths. B) Kaplan-Meier survival analysis of Myc iG7 mTR +/- p53 +/+ (black dashed, n=11) Myc iG7 mTR -/- p53 +/+ (red dashed, n=20), Myc iG7 mTR +/- p53 +/-(black solid, n=7), and Myc iG7 mTR -/- p53 +/- (red, solid n=9) cohorts. Myc p53+/- animals invariably develop Myc p53-/- tumors at around 40 days. Short telomeres promote chromosomal abnormalities in p53 deficient lymphomas. C) Q-FISH analysis of metaphase spreads from Myc mTR +/- p53 -/- (top) and Myc mTR -/-p53 -/- (bottom) lymphomas. Ten metaphases each from three separate lymphomas are represented for each genotype. D) Quantitation of chromosome abnormalities. The number of chromosome end-to-end fusions (red bars) and non-reciprocal translocations (blue bars) per metaphase are shown. (10 metaphases per tumor n=3). Bars indicate standard error.