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. Author manuscript; available in PMC: 2007 Aug 13.
Published in final edited form as: Cancer Cell. 2007 Apr 12;11(5):461–469. doi: 10.1016/j.ccr.2007.02.026

Figure 5.

Figure 5

Micro-lymphomas from Bcl-2; Myc mTR-/- G5/6 animals are senescent. A) Mitotic Indices for Bcl-2; Myc mTR+/+, Bcl-2; Myc mTR-/- G5, and Bcl-2; Myc mTR-/- G6. Bars indicate standard error. B) Histological analysis of Bcl-2; Myc mTR+/+ and Bcl-2; Myc mTR-/- G6 lymphomas. Top) H&E stain showing complete effacement of cervical lymph node in Bcl-2; Myc mTR +/+ and small encapsulated micro-lymphoma surrounded by salivary glands in Bcl-2; Myc mTR-/- G6. Senescence associated β-gal activity, p16INK4a and p15INK4b immuno-stain specifically associated with Bcl-2; mTR -/- G6 micro-lymphomas. Scale bar represents 250 μm for low power hematoxylin and eosin (H&E) stained images (top panels) and 100 μm for all other images.