Table 3.

Parameter estimates (95% confidence intervals) for full and best-fit models for use of illicit psychoactive substances, symptoms of abuse/dependence and the diagnosis of abuse or dependence

		Full			Best-fit
Substance	Phenotype	A	C	E	A	E
Any	Significant use	0.77 (0.54–0.87)	0.00 (0.00–0.19)	0.23 (0.13–0.36)	0.77 (0.64–0.87)	0.23 (0.13–0.36)
	Symptoms of abuse/dependence	0.77 (0.45–0.89)	0.00 (0.00–0.27)	0.23 (0.11–0.42)	0.77 (0.58–0.89)	0.23 (0.11–0.42)
	Abuse or dependence	0.68 (0.00–0.88)	0.00 (0.00–0.56)	0.32 (0.12–0.65)	0.68 (0.35–0.88)	0.32 (0.12–0.65)
Cannabis	Significant use	0.76 (0.51–0.86)	0.00 (0.00–0.20)	0.24 (0.14–0.39)	0.76 (0.61–0.86)	0.24 (0.14–0.39)
	Symptoms of abuse/dependence	0.75 (0.34–0.89)	0.00 (0.00–0.34)	0.25 (0.11–0.47)	0.75 (0.53–0.89)	0.25 (0.11–0.47)
	Abuse or dependence	0.77 (0.05–0.94)	0.00 (0.00–0.56)	0.23 (0.07–0.55)	0.77 (0.46–0.93)	0.23 (0.07–0.54)
Stimulants	Use	0.76 (0.14–0.89)	0.00 (0.00–0.54)	0.24 (0.11–0.44)	0.76 (0.56–0.89)	0.24 (0.11–0.44)
Opiates	Use	0.44 (0.00–0.94)	0.33 (0.00–0.85)	0.23 (0.05–0.60)	0.79 (0.45–0.95)	0.21 (0.05–0.55)
Cocaine	Use	0.44 (0.00–0.80)	0.13 (0.00–0.69)	0.43 (0.19–0.76)	0.58 (0.27–0.80)	0.42 (0.20–0.73)
Psychedelics	Use	0.81 (0.17–0.93)	0.00 (0.00–0.57)	0.19 (0.07–0.40)	0.81 (0.61–0.93)	0.19 (0.07–0.39)