Table 5 Dose–response models for pesticide use variables and farmer's lung in the Agricultural Health Study; models adjusted for base model covariates alone and for all model covariates.
| Exposure variable | Farmer's lung | Adjusted for age, state and smoking | Adjusted for all model covariates* | |||
|---|---|---|---|---|---|---|
| Cases n (%) | Controls n (%) | OR (95% CI) | p Trend† | OR (95% CI) | p Trend† | |
| Farmer models | ||||||
| Mixed/applied pesticides (years) | ||||||
| 1–10 | 64 (15) | 4541 (26) | 1.00 | <0.0001 | 1.00 | 0.0056 |
| 11–20 | 105 (25) | 6534 (33) | 1.08 (0.80 to 1.46) | 0.92 (0.66 to 1.27) | ||
| 21–30 | 148 (35) | 4980 (25) | 1.72 (1.27 to 2.33) | 1.30 (0.93 to 1.81) | ||
| ⩾30 | 109 (26) | 3094 (16) | 2.10 (1.50 to 2.94) | 1.50 (1.03 to 2.20) | ||
| Applied Pesticides (days/year) | ||||||
| 1–4 | 69 (15) | 3709 (19) | 1.00 | 0.0005 | 1.00 | 0.26 |
| 5–9 | 126 (27) | 4974 (25) | 1.16 (0.86 to 1.57) | 1.02 (0.74 to 1.41) | ||
| 10–19 | 153 (32) | 6104 (31) | 1.24 (0.93 to 1.66) | 1.00 (0.72 to 1.36) | ||
| 20–39 | 92 (20) | 3551 (18) | 1.57 (1.14 to 2.17) | 1.23 (0.87 to 1.75) | ||
| ⩾40 | 33 (7) | 1492 (8) | 1.87 (1.22 to 2.87) | 1.16 (0.72 to 1.90) | ||
| Lifetime days of pesticide application | ||||||
| 1–75 | 78 (17) | 5170 (26) | 1.00 | <0.0001 | 1.00 | 0.088 |
| 76–200 | 93 (20) | 4227 (21) | 1.20 (0.88 to 1.62) | 1.09 (0.78 to 1.51) | ||
| 201–400 | 155 (33) | 5083 (26) | 1.65 (1.25 to 2.18) | 1.38 (1.01 to 1.88) | ||
| ⩾401 | 147 (31) | 5304 (27) | 1.71 (1.29 to 2.27) | 1.26 (0.92 to 1.73) | ||
| Spouse models‡ | ||||||
| Mixed/applied pesticides (years) | ||||||
| None | 12 (27) | 13 186 (51) | 1.00 | 0.0012 | ||
| <11 | 11 (25) | 7128 (28) | 1.67 (0.73 to 3.81) | |||
| ⩾11 | 21 (48) | 5649 (22) | 3.29 (1.59 to 6.80) | |||
| Applied pesticides (days/year) | ||||||
| None | 12 (27) | 13 186 (51) | 1.00 | 0.0022 | ||
| <5 | 12 (27) | 6317 (24) | 1.83 (0.82 to 4.11) | |||
| ⩾5 | 20 (46) | 6468 (25) | 3.06 (1.49 to 6.30) | |||
| Lifetime days of pesticide application | ||||||
| None | 12 (27) | 13 186 (53) | 1.00 | 0.0004 | ||
| 1–20 | 6 (14) | 3359 (14) | 1.92 (0.71 to 5.15) | |||
| 21–110 | 10 (23) | 4520 (18) | 2.12 (0.91 to 4.95) | |||
| ⩾111 | 16 (36) | 3694 (15) | 4.03 (1.88 to 8.61) | |||
*Model covariates including all farming exposures in table 2.
†p trend calculated using χ2 test for trend.
‡Fully adjusted models for spouses were not run due to the limited number of cases.