Table 1.

Genotype Frequency of ABCA1 polymorphisms in USA Sib-pair Series

SNP ID (Function)		Total (Nf=331)			ApoE-ε4- (Nf=76)			ApoE-ε4+ (Nf=227)
		Fam#	Freq	P-Value	Fam#	Freq	P-Value	Fam#	Freq	P-Value
rs2422493	C/C	45	0.266	0.62	5	0.245	N/A	25	0.284	0.62
(promoter)	T/C	79	0.494	0.17	14	0.494	0.29	38	0.489	0.35
	T/T	44	0.241	0.02*	10	0.261	0.30	21	0.227	0.08
rs2230806	A/A	17	0.095	0.93	2	0.058	N/A	10	0.111	0.86
(R219K)	A/G	66	0.399	0.23	12	0.483	0.01*	31	0.388	0.70
	G/G	56	0.507	0.21	11	0.459	0.02*	25	0.500	0.59
rs2066718	A/A	0	0	N/A	0	0	N/A	0	0	N/A
(V771M)	A/G	14	0.100	0.69	2	0.162	N/A	6	0.102	N/A
	G/G	14	0.900	0.69	2	0.838	N/A	6	0.898	N/A
rs2230808	A/A	15	0.066	0.06	5	0.044	N/A	8	0.064	N/A
(R1587K)	A/G	62	0.426	0.69	14	0.505	0.64	32	0.420	0.90
	G/G	56	0.509	0.55	13	0.451	0.57	29	0.515	0.67

^*: significant p-value

Fam#: Number of informative families

Freq: Frequency

Nf: Number of Nuclear Families

N/A: non applicable