Table II.
Parameter estimates from segregation analysis of prostate cancer in 557 early-onset Finnish families ascertained through a single prostate cancer proband aged <61 years
| Value of parameter
|
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hypothesis | -2ln L | AIC | df | χ2 | P | qA | τAA | τAB | τBB | βAA | βAB | βBB | α | γ | F(aff) |
| 1. No major gene | 479.02 | 487.02 | 6 | 18.36 | 0.005 | [1.0] | - | - | - | −53.73 (5.31) | =βAA | =βAA | 0.20 (0.014) | 1.0 (0.0) | 3.4 (0.25) |
| 2. Dominant | 473.08 | 485.08 | 4 | 12.42 | 0.014 | 0.9421 (0.597) | [1.0] | [0.5] | [0.0] | −62.27 (5.56) | =βAA | −57.97 (4.32) | 0.24 (0.019) | 1.0 (0.0) | 3.4 (0.24) |
| 3. Codominant | 474.18 | 488.18 | 3 | 13.52 | 0.036 | 0.0000007 (0.0) | [1.0] | [0.5] | [0.0] | −41.41 (3.67) | −63.40 (4.48) | −85.39 (7.01) | 0.25 (0.017) | 1.0 (0.0) | 3.4 (0.33) |
| 4. Recessive | 462.20 | 474.20 | 4 | 1.54 | 0.8266 | 0.0536 (0.01) | [1.0] | [0.5] | [0.0] | −60.11 (4.11) | −64.63 (5.55) | =βAB | 0.25 (0.021) | 1.0 (0.0) | 3.7 (0.41) |
| 5. Environmental | 465.76 | 481.76 | 2 | 5.1 | 0.082 | 0.4183 (0.24) | 1.0 (0.0) | =τAA | =τAA | −77.25 (7.01) | −79.69 (8.34) | −68.55 (6.98) | 0.27 (0.036) | 1.0 (0.0) | 3.3 (0.31) |
| 6. General | 460.66 | 480.66 | - | - | - | 0.7328 (0.45) | 1.0 (0.0) | 0 (0.0) | 0 (0.0) | −65.08 (6.93) | −67.98 (7.01) | −76.79 (7.86) | 0.26 (0.019) | 1.0 (0.0) | 3.0 (0.30) |
χ2 is defined as (-2ln L) of the data under the hypothesis minus (-2ln L) of the data under the general model. Numbers in brackets are fixed at the indicated value; qA : the frequency of the putative high-risk allele; τ: transmission parameter denoting the probability that a parent of a given type transmits the disease-producing factor A to his or her offspring; β: baseline parameter; α: age adjustment parameter; γ: susceptibility parameter describing the cumulative probability of prostate cancer (assuming infinite lifespan).