Table IV.
Parameter estimates from segregation analysis of prostate cancer in combined analysis of two cohorts of 1,546 Finnish families ascertained through a single prostate cancer proband
| Value of parameter
|
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hypothesis | -2ln L | AIC | df | χ2 | P | qA | τAA | τAB | τBB | βAA | βAB | βBB | α | γ | F(aff) |
| 1. No major gene | 1884.38 | 1892.38 | 6 | 110.04 | <0.001 | [1] | [1] | [0.5] | [0] | −54.26 (5.21) | =βAA | =βAA | 0.17 (0.014) | 1.0 (0.0) | 3.47 (0.35) |
| 2. Dominant | 1830.36 | 1842.36 | 4 | 56.02 | <0.001 | 0.0022 (0.001) | [1] | [0.5] | [0] | −61.57 (5.98) | =βAA | −65.77 (5.92) | 0.21 (0.018) | 1.0 (0.0) | 3.50 (0.47) |
| 3. Codominant | 1806.42 | 1820.42 | 3 | 32.08 | <0.001 | 0.1012 (0.007) | [1] | [0.5] | [0] | −70.16 (6.23) | −74.68 (7.26) | −86.40 (8.11) | 0.23 (0.010) | 1.0 (0.0) | 3.20 (0.45) |
| 4. Recessive | 1783.12 | 1795.12 | 4 | 8.78 | 0.07 | 0.0903 (0.005) | [1] | [0.5] | [0] | −63.34 (6.01) | −71.23 (6.75) | =βAB | 0.22 (0.013) | 1.0 (0.0) | 3.90 (0.53) |
| 5. Environmental | 1866.34 | 1882.34 | 2 | 92.0 | <0.001 | 0.4868 (0.061) | 0 (0.0) | =βAA | =βAA | −55.74 (5.64) | −79.41 (8.04) | −56.10 (4.34) | 0.18 (0.011) | 1.0 (0.0) | 3.32 (0.33) |
| 6. General | 1774.34 | 1794.34 | - | - | - | 0.9542 (0.004) | 1.0 (0.0) | 1.0 (0.0) | 1.0 (0.0) | −49.77 (4.7) | −53.49 (5.62) | −57.31 (5.89) | 0.16 (0.014) | 1.0 (0.0) | 3.20 (0.29) |
χ2 is defined as (-2ln L) of the data under the hypothesis minus (-2ln L) of the data under the general model. Numbers in brackets are fixed at the indicated value; qA : the frequency of the putative high-risk allele; τ: transmission parameter denoting the probability that a parent of a given type transmits the disease-producing factor A to his or her offspring; β: baseline parameter; α: age adjustment parameter; γ: susceptibility parameter describing the cumulative probability of prostate cancer (assuming infinite lifespan).