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Effect of LNSV-AT1R-AS treatment on mean BP in WKY and SH rats. Five-day-old WKY and SH rats treated with physiological saline (control), LNSV, and LNSV + AT1R-AS were allowed to mature for 120 days. Mean BP was measured through catheters implanted in the carotid artery. A single injection of LNSV + AT1R-AS into neonatal SH rats prevented the increase in BP. There was not a significant effect of LNSV or LNSV + AT1R-AS on the mean BP in the WKY. Data are expressed as mean ± SE (n = 6).
