Table 5.
Differential expression of human XRRA1 in XR-treated HCT116 clones, in normal tissues/organs and cells, as well as in various cancer cell types.
| Cells/Tissues/Organs | Relative Expression Level (Normalized against G3PDH)* | Cell/Tissue/Organ type; Cancer Type |
| HCT116Clone2_XRR | +++ | Colorectal, more resistant to X-radiation than HCT116 |
| HCT116Clone10 | ++++ | Colorectal, similar radiation response to HCT116 |
| HCT116CloneK_XRS | ++++++ | Colorectal, more sensitive to X-radiation than HCT116 |
| HCT116Clone2_XRR | +++ | Without X-radiation |
| HCT116Clone2_XRR M10 | ++++ | 10 Minutes after X-radiation |
| HCT116Clone2_XRR H6 | ++ | 6 Hours after X-radiation |
| HCT116Clone2_XRR H24 | + | 24 Hours after X-radiation |
| HCT116Clone10 | ++++ | Without X-radiation |
| HCT116Clone10 M10 | + | 10 Minutes after X-radiation |
| HCT116Clone10 H6 | + | 6 Hours after X-radiation |
| HCT116Clone10 H24 | + | 24 Hours after X-radiation |
| HCT116CloneK_XRS | ++++++ | Without X-radiation |
| HCT116CloneK_XRS M10 | + | 10 Minutes after X-radiation |
| HCT116CloneK_XRS H6 | + | 6 Hours after X-radiation |
| HCT116CloneK_XRS H24 | ++++ | 24 Hours after X-radiation |
| Testis | ++++++++ | Normal |
| Prostate | +++++ | Normal |
| Ovary | +++++ | Normal |
| Leukocyte | ++ | Normal |
| Spleen | + | Normal |
| Thymus | ++ | Normal |
| Small Intestine | ++ | Normal |
| Colon | + | Normal |
| AG1522 | ++++ | Normal fibroblast (immortalized) |
| COS-7 | +++ | Normal fibroblast (immortalized) |
| HDMEC | ++++ | Normal microvascular endothelial (primary) |
| MCF7 | + | Breast cancer |
| MDA MB435 | +++++ | Breast cancer |
| U251MG | + | Glioma |
| SKMEL-3 | + | Melanoma |
| HT144 | + | Melanoma |
| HTB56 | +++ | Lung cancer |
| A594 | ++++ | Lung cancer |
| Daoy | ++++ | Neuroblastoma |
| SKNA | +++ | Neuroblastoma |
| SHSY | ++++ | Neuroblastoma |
| A2780CP | + | Ovarian cancer, resistant to cisplatin |
| OCCL | ++++ | Ovarian cancer |
| OV2008 | ++++ | Ovarian cancer |
| C13 | +++ | Ovarian cancer |
| 433 | + | Ovarian cancer |
| SKOV3 | ++ | Ovarian cancer |
| HEY | ++++ | Ovarian cancer |
| 429 | +++ | Ovarian cancer |
| PC-3 | + | Prostate cancer |
| DU145 | +++++ | Prostate cancer |
| SN12C | + | Renal cancer |
| HT29 | + | Colorectal cancer |
| K-562 | +++++ | Leukemia |
| Mm TM28 | +++ | (Murine) Fibrosarcoma |
| Mm FS-TM28 | + | (Murine) Fibrosarcoma biopsy |
| Mm ES-R1 | ++ | (Murine) Embryonic Stem Cell |
*+, very low; ++, low; +++ moderate; >++++, high.