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. 1996 Nov 26;93(24):13884–13889. doi: 10.1073/pnas.93.24.13884

Figure 5.

Figure 5

Analysis of the HB1-element in the context of the ftz enhancer. (A) Deletion constructs of the ftz autoregulatory element and fusion constructs to HB1. ▪, FTZ binding sites; ░⃞, Hoxa-7 HB1-elements. AE13 contains several FTZ binding sites, AE20A a single binding site. Both exhibit enhancer activity in alternate segments in the mesoderm. AE21 is not functional. In 4A7ftz, the FTZ binding site and a binding site for FTZ-F1 (□) has been replaced by the HB1-element. (B) Sequence comparison of the ftz sequence in AE20A and the homeodomain binding sites in 4A7ftz. Binding sites for FTZ and FTZ-F1 as well as the homeodomain binding sites (HD) are indicated.