Table 5.

Amino acid substitution table for buried hydrophobic residues

Buried residue	Conservative substitutions	Nonconservative substitutions
Val	Ala, Phe	Gly, Asp, Thr
Ile	Phe, Cys	Gly, Glu, Thr
Leu	Phe, Val	Gly, Glu, Thr
Met	Phe, Val	Gly, Glu, Thr
Phe	Leu, Met	Gly, Glu, Thr
Cys	Val, Met	Gly, Asp, Ser
Trp	Phe, Leu	Gly, Glu, Thr