Figure 5.

Expression patterns in Hr-CMV mice. When crossed with albino hairless mice, the transgenic mice showed substantially less signal in the skin than the haired transgenic mice and internal structures were visible. (A) Reference image of an overdosed adult Hr-CMV mouse. (B) Linear scaling of intensity showed detail of the brightest areas, and (C) logarithmic scale revealed subtle differences in expression in the ear canal, joints, and muscle in the same image. (D) Reference image of a second adult Hr-CMV mouse taken with f/1.2 lens and +4 close-up filter (Promaster), (E) linear scale, and (F) logarithmic scale of same image. Highest signal was from the tail (B), internal organs (E), some skeletal muscles (B), ear canals (C and F), claws (F), skull (B and E), joints (C) and the underside of the paws (C and F). Note that some dark, non-expressing structures that obscure background light are visible (C and F, black arrows).