Figure 1.

The basic data-type of ELISA. The template is created from a characteristic three-dimensional structure of a domain and all sequences that fold into this domain. All sequences from the domain are mined for functional annotation, and this functional annotation is used to build a "consensus tree". This consensus tree represents all possible functions of the collection of sequences that fold into a structure. The multiple sequence alignment is also used in finding close homologous sequences in all fully sequenced proteomes.