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Analysis of ASA in the crystal structure of human muscle LDH subunits. (A) Comparison of the residue-accessible surface area of the loop-open and loop-closed subunits. (B) Subtracting the loop-closed ASA from the loop-open ASA to identify hot spots of rearrangement. (C) Subtracting the ASA of residues in the loop-open ternary from the loop-open binary complex to highlight the residues that are shielded from the solvent as a result of ligand binding.
