TABLE 1.
Accessible surface area of each binary complex of human muscle LDH in the context of the tetrameric biological unit
| Subunit | Binary | Nonpolar | Backbone (N and O) |
|---|---|---|---|
| A | 9794 | 2190 | 884 |
| B | 9865 | 2272 | 894 |
| C | 9590 | 2228 | 911 |
| D | 10712 | 2483 | 938 |
The tetramer that was examined comprises LDH chains A, B, C, and D of PDB ID 1I10. The contribution from the nonpolar residues and the backbone N and O atoms were also calculated. ASA are reported in units of Å2. The most open and most tight binary complexes differ by 1122.53 Å2 in solvent exposure. For reference, the ASA of a solvent-exposed Ile is 80 Å2 and exposed Val has an ASA equal to 71 Å2 using a probe radius of 1.4 Å.