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Sensitivity of damage detection increases with plasmid size. (A) An AFM image of supercoiled plasmid pNEBR-R1 (10,338 basepairs) irradiated at 29 J/m2 UVB. Scan size 3 × 3 μm2. (B) Percentages of different configurations of pNEBR-R1 plasmids determined from AFM images such as these shown in A. Color code is the same as in Fig. 2.
