FIGURE 3.

Contractile performance of hearts bearing R-92 cTnT mutations under baseline perfusion conditions (left columns) and at high workload (right columns) in response to either 4 mM Ca²⁺ when not paced or paced at 420 bpm or 300 nM Dobutamine. Data shown are mean ± SE, n = 3–6. For the pairs from top to bottom: (A) heart rate at baseline and (B) heart rate at high workload; (C) developed pressure (difference between left ventricular systolic pressure and end diastolic pressure) at baseline and (D) developed pressure at high workload; (E) +dp/dt at baseline, and (F) +dp/dt at high workload; (G) −dp/dt at baseline, and (H) −dp/dt at high workload. *p < 0.05; ^†p < 0.01 vs nTG; ^‡p < 0.05; ^‖p < 0.01 vs. baseline.