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. 2007 Aug 9;26(17):3993–4004. doi: 10.1038/sj.emboj.7601827

Figure 7.

Figure 7

Illustration of filamin domain arrangements. (A) ddFLN Ig domain 4–6. (B) Human IgFLNa19–21. (C) A hypothetical model of two filamin domain pairs showing that in this kind of arrangement the N- and C-termini of the four-domain fragment would be close to each other. Additional IgFLN domains or domain pairs can be accommodated in this model by allowing flexibility in the interdomain linker regions. (D) A hypothetical model showing how binding of an integrin β-tail (arrow) to IgFLNa21 might affect the overall arrangement of IgFLNa18–21. Our data do not indicate whether ligand binding to one domain pair impacts adjacent domain pairs.