Table 1.

Patches of p53-mutated keratinocytes in human epidermis

Sample	Age	Location	Patch frequency, cm−2	Normal sequence	Base change	Codon	Amino acid change
Sun-shielded
YC19A	24	Inner arm	1
YC17A	28	Abdomen	4
YC7A	29	Breast	1
YC8A	32	Breast	4
YC4A	40	Lower abdomen	3
YC13A	41	Breast	7
YC18A	44	Inner arm	2
YC14A	47	Lower abdomen	0
YC6A	50	Breast	8
Intermittent
YC19B.1	24	Upper back	11	tCCg	CC → TT/wt	248	Arg → Gln
YC19B.2				tCCg	CC → TT/wt	248	Arg → Gln
				tcCca	C → T/wt	279	Gly → Glu
YC19B.3					wt
YC9A	31	Left thigh	6
YC18B	44	Upper back	7
YC5A	47	Post-auricular	8
YC2A	48	Post-auricular	9
YC2B.1	48	Post-auricular	38	gtCcc	C → T/wt	266	Gly → Glu
YC10A	70	Right thigh	6
Chronic exposure
YC12A	9	Lip	46		wt
YC24A	43	Pre-auricular	23
YC5B.1	47	Pre-auricular (left)	29	gcTcc	ΔT/wt	362	… Stop
YC5B.2					wt
YC5C	47	Pre-auricular (right)	45
YC2C.1	48	Lower eyelid	32		wt
YC2D.1	48	Pre-auricular	23		wt
YC2D.2					wt
YC2D.3					wt
YC2E	48	Pre-auricular	33
YC23A	51	Upper eyelid (right)	24
YC23B	51	Upper eyelid (left)	25
YC15A	53	Lower eyelid	44
YC15B.1	53	Lower eyelid	41	taCac	C → T/wt	81	Thr → Ile
YC15B.2				aCg	C → T/wt	273	Arg → His
YC1A	65	Lower eyelid (right)	36
YC1B.1	65	Lower eyelid (left)	37	tCCg	CC → TT/wt	248	Arg → Gln
YC1B.2					wt
YC1B.3					wt
YC1B.4					wt
YC22A	66	Upper eyelid (right)	33
YC22B	66	Upper eyelid (left)	25
YC11A	74	Pre-auricular	39
YC3A	79	Upper eyelid	27		wt

Each YC number denotes a different individual, letters denote different tissues, and decimal numbers denote sequenced patches. Both compact and diffuse patches were counted. Nucleotide sequences are for the strand containing the mutating pyrimidine. wt denotes the presence of a wild-type allele, alone or with a mutant allele.