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. Author manuscript; available in PMC: 2007 Aug 15.
Published in final edited form as: Free Radic Biol Med. 2006 Sep 9;41(12):1771–1780. doi: 10.1016/j.freeradbiomed.2006.08.025

Table 1.

Lipid peroxidation (LPO) and antioxidants in L-NAME treated control and NY1DD mice

Tissue C57BL mice NY1DD mice
Untreated L-NAME Untreated L-NAME
1. Lipid peroxidation
A. Desferal + BHT (nmol/mg protein)
 i. Muscle
 ii. Liver 		n=3

0.59 ± 0.01
0.32 ± 0.02		 n=3

2.4 ± 0.1*
0.63 ± 0.01* 		n=3

1.19 ± 0.02
0.69 ± 0.04		 n=3

2.61 ±0.1*
1.52 ± 0.28*
B. 8-Isoprostane (ng/g tissue), liver 0.87 ±0.12 1.93 ±0.06* 1.67 ±0.1 2.2 ±0.06*
2. GSH (nmol/g tissue)
 i. Muscle
 ii. Kidney
 iii. Liver 		n=6
52.3 ± 6.9
98.0 ± 18.2
251.3 ± 20.5		 n=4
51.5 ± 6.1
96.8 ± 3.1
235.4 ± 33.1		 n=6
28.5 ± 5.3*
46.5 ± 2.1*
138.1 ± 7.7* 		n=4
18.3 ± 1.8+
28.2 ± 5.1+
104.4 ± 5.7*
3. SOD (μmol/mg protein)
 i. Muscle
 ii. Kidney
 iii. Liver 		n=6
13.7 ± 1.4
9.5 ± 1.4
18.5 ± 2.4		 n = 4
9.6 ± 1.3*
3.6 ± 0.8*
11.6 ± 0.3* 		n = 6
8.3 ± 0.5*
6.3 ± 0.6*
8.8 ± 1.2* 		n= 4
6.7 ± 0.2+
4.4 ± 0.4+
6.6 ± 1.1+
4. Catalase (μmol H2O2/min/ mg protein)
 i. Muscle
 ii. Kidney
 iii. Liver 		n=6
54.5 ± 7.1
197.7 ± 19.7
231.2 ± 41.3		 n= 4
27.1 ± 5.3*
118.8 ± 5.8*
124.9 ± 17.6* 		n=6
22.9 ± 2.0*
125.6 ± 24.7*
149.8 ± 15.4* 		n= 4
17.7 ± 3.7+
69.6 ± 18.0+
93.6 ± 8.5+
5. GPx (nmol NADPH/min/ mg protein)
 i. Muscle
 ii. Kidney
 iii. Liver 		N=6
61.9 ± 5.0
39.2 ± 6.8
33.7 ± 3.4		 n= 4
28.4 ± 2.7*
21.5 ± 1.1*
17.±1.5* 		n=6
38.4 ± 2.4*
23.3 ± 4.4*
17.0 ± 2.7* 		n= 4
14.7 ± 2.3+
18.5 ± 2.8+
9.8 ± 2.4+

Values are expressed as mean ± SD

*

P<0.01 vs untreated C57BL mice;

+

P<0.01 vs. untreated NY1DD mice.