Figure 3.
(A) Expression of Myc-R2 in ras-transformed cells resulted in an increased growth efficiency in soft agar. Examples shown are r-3/mR2 and uninfected r-3 cells. (See Table 1 for further information.) (B) C1/mR2 cells showed reduced tumor latency and increased growth rate when compared with C1/SH control cells. Three ×105 cells from logarithmically growing cultures were collected and subcutaneously injected into five syngeneic C3H/HeN mice per cell line per experiment. Results presented were from two independent experiments. The P value of t test analysis of tumor growth rates is shown, and indicates that the growth rates for the two cell lines are significantly different. (C) C1/mR2 cells exhibited elevated metastatic potential.