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. 2007 Jul 12;26(15):3534–3544. doi: 10.1038/sj.emboj.7601791

Figure 6.

Figure 6

A model of the molecular mechanism of the PKA- or PAK1-induced tamoxifen resistance. In the presence of tamoxifen, SRC-1 binds to the AF-1 but not to the AF-2 domain of ERα. Phosphorylation of ERα-S305 by PKA results in an altered orientation between the C-termini of ERα and SRC-1, which differs from the orientation under conditions of CTS. This ERα-S305-specific phosphorylation by PKA leads to recruitment of RNA polymerase II and to elevated transcription in the presence of tamoxifen.