Table 1.
T-cell populations
| Cell count × 10−6 (mean±s.d) | DN (%) | DP (%) | CD4 SP (%) | CD8SP (%) | |
|---|---|---|---|---|---|
| Thymus | |||||
| Wild type (n=5) | 68.75 (28.3) | 4.98 (1.12) | 85.25 (0.54) | 7.35 (0.95) | 2.19 (0.23) |
| vMyb4 (n=5) | 122.5 (35.9) | 3.49 (0.29) | 89.62 (0.49) | 6.4 (0.27) | 0.5 (0.05) |
| P-value, H0=identical mean | 0.059 | 0.072 | 0.00005 | 0.14 | 0.0004 |
| MybF/F (n=13) | 120.98 (54.3) | 6.85 (1.98) | 77.67 (3.51) | 11.10 (1.98) | 4.34 (0.49) |
| MybF/FCD4Cre (n=19) | 120.03 (57.76) | 10.76 (3.86) | 76.22 (6.23) | 6.42 (1.57) | 6.57 (1.84) |
| P-value, H0=identical mean | 0.909 | 0.0002 | 0.368 | 1.83E-08 | 1.29E-05 |
| MybF/FOTIIRag2−/− (n=3) | 4.83 (1.79) | 32 (5.29) | 38.36 (3.19) | 27.46 (5.35) | |
| MybF/FCD4Cre OTII Rag2−/−(n=3) | 2.96 (0.45) | 38.66 (9.07) | 48.7 (8.32) | 11.51 (2.76) | |
| P-value, H0=identical mean | 0.208 | 0.346 | 0.153 | 0.019 | |
| HYRag2−/− (n=7) | 57 (28.6) | 21.65 (4.31) | 59.25 (10.21) | 18 (8.17) | |
| vMyb HYRag2−/− (n=9) | 86.88 (67.7) | 11.58 (1.83) | 84.36 (2.62) | 3.35 (2.20) | |
| P-value, H0=identical mean | 0.257 | 0.0004 | 0.0004 | 0.002 | |
| NSHYRag2−/− (n=3) | 53 (7.5) | 25.66 (7.49) | 66.33 (3.51) | ||
| vMybNSHYRag2−/− (n=3) | 70.34 (15.4) | 13.76 (1.87) | 83.5 (2.29) | ||
| P-value, H0=identical mean | 0.083 | 0.102 | 0.003 | ||
| F5 (n=3) | 91.3 (27.2) | 9.20 (5.42) | 71.93 (6.72) | 4.52 (1.22 | 14.56 (1.98) |
| vMybF5 (n=5) | 171.6 (59.9) | 4.86 (1.19) | 75.96 (3.20) | 16.96 (1.59) | 2.33 (0.59) |
| P-value, H0=identical mean | 0.042 | 0.299 | 0.41 | 3.77E-05 | 0.006 |
| Spleen | |||||
| MybF/F (n=5) | 75.8 (3.19) | 17.3 (7.21) | 9.34 (4.82) | ||
| MybF/FCD4Cre (n=5) | 54.8 (11.9) | 10.75 (2.98) | 8.078 (1.93) | ||
| P-value, H0=identical mean | 0.478 | 0.116 | 0.608 | ||
| HYRag2−/− | |||||
| (n=3) | 10.5 (4.27) | 23.66 (7.76) | |||
| vMyb HYRag2−/− | |||||
| (n=4) | 8.75 (2.75) | 0.9 (0.26) | |||
| P-value, H0=identical mean | 0.57 | 0.03 | |||
| F5 (n=3) | 84.6 (32.57) | 9.26 (2.13) | 37.23 (2.65) | ||
| vMybF5 (n=5) | 78 (23.4) | 15.42 (1.49) | 1.45 (0.38) | ||
| P-value, H0=identical mean | 0.77 | 0.019 | 0.001 | ||