Skip to main content
. Author manuscript; available in PMC: 2008 Jun 20.
Published in final edited form as: Maturitas. 2006 Dec 21;57(2):120–131. doi: 10.1016/j.maturitas.2006.11.009

Table 2.

Association between genotype and sex steroid hormone levels

Testosterone Androstenedione DHEA-S Estradiol Estrone Progesterone
Genotype n Geometric Mean* (95% CI) p-value Geometric Mean* (95% CI) p-value Geometric Mean* (95% CI) p-value Geometric Mean* (95% CI) p-value Geometric Mean* (95% CI) p-value Geometric Mean* (95% CI) p-value
 CYP1B1
  +/+ 161 0.499 (0.454, 0.548) 0.1 2.109 (1.948, 2.280) 0.2 403.83 (369.08, 441.86) 0.08 99.98 (88.41, 112.96) 0.7 135.64 (122.12, 150.51) 0.6 0.960 (0.766, 1.202) 0.07
  +/− or −/− 461 0.457 (0.433, 0.483) 1.986 (1.896, 2.077) 367.23 (348.63, 386.84) 97.13 (90.56, 104.27) 131.24 (123.59, 139.49) 0.752 (0.660, 0.857)
  Missing 3
 CYPc17α
  +/+ 224 0.472 (0.437, 0.511) 0.8 2.090 (1.960, 2.230) 0.2 382.22 (354.96, 411.58) 0.6 104.17 (94.16, 115.12) 0.1 134.42 (123.35, 146.50) 0.7 0.807 (0.670, 0.972) 1.0
  +/− or −/− 401 0.467 (0.440, 0.495) 1.982 (1.890, 2.081) 373.53 (353.19, 394.65) 94.54 (87.71, 101.90) 131.63 (123.47, 140.33) 0.803 (0.698, 0.922)
 CYP1A1
  +/+ 487 0.471 (0.447, 0.497) 0.7 2.004 (1.917, 2.094) 0.4 378.80 (359.96, 398.22) 0.7 98.49 (91.93, 105.43) 0.7 133.09 (125.59, 141.17) 0.8 0.819 (0.722, 0.929) 0.5
  +/− or −/− 138 0.460 (0.416, 0.508) 2.079 (1.913, 2.259) 369.44 (335.96, 406.26) 95.87 (84.27, 109.07) 130.97 (117.33, 146.20) 0.754 (0.594, 0.956)
 CYP19
  +/+ 193 0.437 (0.401, 0.476) 0.06 1.960 (1.824, 2.104) 0.3 342.41 (315.77, 371.67) 0.006 94.73 (84.86, 105.74) 0.4 127.74 (116.16, 140.47) 0.3 0.796 (0.648, 0.979) 0.9
  +/− or −/− 426 0.483 (0.457, 0.512) 2.052 (1.958, 2.153) 393.86 (373.16, 415.72) 100.38 (93.32, 107.99) 135.64 (127.36, 144.46) 0.812 (0.708, 0.931)
  Missing 6
 COMT
  +/+ 160 0.468 (0.427, 0.514) 1.0 2.050 (1.898, 2.217) 0.7 382.99 (350.72, 418.64) 0.7 99.78 (88.23, 112.84) 0.7 128.51 (115.82, 142.59) 0.5 0.786 (0.629, 0.982) 0.8
  +/− or −/− 464 0.469 (0.444, 0.495) 2.012 (1.923, 2.104) 374.28 (355.31, 394.26) 97.22 (90.47, 104.48) 134.02 (126.09, 142.45) 0.807 (0.709, 0.919)
  Missing 1
 βHSD
  +/+ 104 0.460 (0.409, 0.513) 0.7 1.964 (1.784, 2.164) 0.6 375.40 (336.30, 419.47) 0.9 105.32 (90.38, 122.73) 0.4 138.38 (121.63, 157.43) 0.6 0.942 (0.715, 1.242) 0.2
  +/− or −/− 510 0.468 (0.444, 0.492) 2.018 (1.933, 2.106) 373.90 (356.02, 392.68) 97.51 (91.10, 104.38) 133.09 (125.71, 141.03) 0.775 (0.685, 0.876)
  Missing 11
*

adjusted for age, race, smoking status, BMI, days since last menstrual period