Table 4.

Association between FEI, FTI, androgen to estrogen ratio, and hot flash variables

		Free Estradiol Index (FEI)		Free Testosterone Index (FTI)		Ratio of total androgens to total estrogens†
Variable	n	Geometric Mean* (95% CI)	p-value	Geometric Mean* (95% CI)	p-value	Geometric Mean* (95% CI)	p-value
Hot Flashes in the past 30 days
Never	265	0.703 (0.628, 0.788)	0.04	2.729 (2.465, 3.019)	0.1	9.337 (8.611, 10.115)	0.002
No (with ever hot flashes)	115	0.574 (0.485, 0.680)		2.581 (2.219, 2.998)		10.268 (9.116, 11.565)
Yes	242	0.577 (0.511, 0.652)		3.071 (2.757, 3.421)		11.658 (10.708, 12.692)
Severity of Hot Flashes
Never	265	0.702 (0.626, 0.787)	0.04	2.735 (2.472, 3.025)	0.7	9.365 (8.637, 10.145)	0.007
Mild	132	0.600 (0.512, 0.704)		2.912 (2.529, 3.353)		10.957 (9.796, 12.256)
Moderate/Severe	227	0.564 (0.499, 0.637)		2.881 (2.583, 3.209)		11.257 (10.329, 12.268)
Frequency of Hot Flashes
Never	265	0.703 (0.627, 0.788)	0.02	2.729 (2.469, 3.019)	0.4	9.346 (8.619, 10.125)	0.001
Monthly	158	0.572 (0.495, 0.662)		2.656 (2.337, 3.016)		10.486 (9.459, 11.612)
At least weekly	178	0.548 (0.476, 0.632)		2.989 (2.638, 3.387)		12.061 (10.903, 13.330)
Duration of Hot Flashes
Never	265	0.702 (0.626, 0.787)	0.04	2.732 (2.469, 3.022)	0.3	9.356 (8.645, 10.135)	0.002
≥ 1 year	233	0.594 (0.527, 0.670)		2.787 (2.504, 3.099)		10.633 (9.777, 11.565)
< 1 year	117	0.551 (0.466, 0.652)		3.127 (2.694, 3.629)		11.989 (10.665, 13.491)

^*adjusted for age, race, smoking status, BMI, days since last menstrual period

^†total androgens = androstenedione plus testosterone, total estrogens = estradiol plus estrone