Table 5.
Risk ratios of experiencing hot flashes by genotype
| Women without hot flashes | Women with hot flashes | Any hot flashes RR* (95% CI) | Women with hot flashes | Moderate or severe hot flashes RR* (95% CI) | Women with hot flashes | At least weekly hot flashes RR* (95% CI) | Women with hot flashes | Hot flashes for ≥1 year RR* (95% CI) | |
|---|---|---|---|---|---|---|---|---|---|
| 3βHSD | n | n | n | n | n | ||||
| +/+ | 54 | 53 | 1.00 | 28 | 1.00 | 25 | 1.00 | 30 | 1.00 |
| +/− or −/− | 210 | 311 | 1.18 (0.96, 1.46) | 203 | 1.38 (1.00, 1.90) | 158 | 1.29 (0.91, 1.83) | 208 | 1.36 (0.99, 1.86) |
| Missing | 3 | 8 | 5 | 5 | 4 | ||||
| CYP19 | |||||||||
| +/+ | 81 | 118 | 1.00 | 73 | 1.00 | 54 | 1.00 | 79 | 1.00 |
| +/− or −/− | 184 | 250 | 1.00 (0.86, 1.17) | 162 | 1.03 (0.83, 1.28) | 130 | 1.10 (0.85, 1.43) | 161 | 0.99 (0.81, 1.22) |
| Missing | 2 | 4 | 1 | 4 | 2 | ||||
| COMT | |||||||||
| +/+ | 67 | 98 | 1.00 | 56 | 1.00 | 52 | 1.00 | 62 | 1.00 |
| +/− or −/− | 199 | 274 | 0.98 (0.84, 1.14) | 180 | 1.06 (0.84, 1.34) | 137 | 0.94 (0.73, 1.21) | 180 | 1.00 (0.81, 1.25) |
| Missing | 1 | 0 | 0 | 0 | 0 | ||||
| CYP1B1 | |||||||||
| +/+ | 77 | 87 | 1.00 | 50 | 1.00 | 39 | 1.00 | 53 | 1.00 |
| +/− or −/− | 189 | 283 | 1.18 (1.00, 1.40) | 185 | 1.33 (1.04, 1.71) | 148 | 1.37 (1.02, 1.84) | 189 | 1.33 (1.05, 1.69) |
| Missing | 1 | 2 | 1 | 1 | 2 | ||||
| 3βHSD, CYP1B1 | |||||||||
| +/+, +/+ | 14 | 10 | 1.00 | 6 | 1.00 | 4 | 1.00 | 3 | 1.00 |
| +/+ and +/− or −/−, or +/− or −/− and +/+ | 100 | 119 | 1.23 (0.75, 2.01) | 66 | 1.22 (0.60, 2.45) | 56 | 1.50 (0.61, 3.67) | 77 | 2.24 (0.79, 6.35) |
| +/− or −/− and +/− or −/− | 149 | 233 | 1.42 (0.88, 2.30) | 158 | 1.63 (0.82, 3.21) | 122 | 1.91 (0.80, 4.60) | 158 | 2.77 (0.99, 7.80) |
| Missing | 4 | 10 | 6 | 6 | 4 | ||||
| p-for-trend | 0.02 | 0.006 | 0.02 | 0.003 |
*
adjusted for race