Table 1.

Cholesterol ester and free cholesterol content of tissues

Tissue	Acact genotype	n	Lipid content, μg/mg protein
			CE	FC
Adrenal	+/+	3	105.4 ± 9.7	11.5 ± 2.7
	+/−	3	53.9 ± 5.1†	10.3 ± 2.3
	−/−	3	3.3 ± 0.6†	7.1 ± 0.6
Liver	+/+	5	2.7 ± 0.1	9.5 ± 1.7
Chow diet	−/−	5	1.9 ± 0.5†	8.7 ± 2.5
Liver	+/+	3	346.0 ± 119	30.5 ± 8.3
High fat diet	−/−	3	350.0 ± 42	31.0 ± 4.3
Peritoneal	+/+	2*	130.0 ± 33	36.1 ± 1.2
macrophages	−/−	3*	7.9 ± 4.8†	72.3 ± 23.8‡

Data are x̄ ± SD. Data are from female mice except for peritoneal macrophages, which were obtained from male mice. CE, cholesterol ester; FC, free cholesterol. 

^*Each sample represents pooled lipid extracts of macrophages from four mice. 

^†P < 0.01 vs. +/+. 

^‡P = 0.13 vs. +/+.