Table 2.

Plasma lipids of wild-type and ACAT-deficient mice

Diet	Acact genotype	n	Plasma lipid concentration, mg/dl
			TC	HDL-C	TG
Chow*	+/+	8	57 ± 19	48 ± 12	60 ± 20
	+/−	5	70 ± 19	52 ± 13	57 ± 7
	−/−	7	123 ± 29‡§	83 ± 19‡§	63 ± 22
High-fat†	+/+	8	170 ± 61	54 ± 18	35 ± 17
	+/−	10	207 ± 56	66 ± 21	35 ± 12
	−/−	10	240 ± 48‡	89 ± 21‡§	29 ± 9

Data are x̄ ± SD. TC, total cholesterol; HDL-C, HDL cholesterol; TG, triglycerides. 

^*Female mice fed standard chow for 3–5 months. 

^†Male and female mice fed a high-fat, high-cholesterol diet for 6–10 weeks. 

^‡P < 0.05 vs. +/+. 

^§P < 0.05 vs. +/−.