Figure 5.

Plot depicting differences in the mean spectra of the IDC and RMT groups versus differences in the mean spectra of the IDC and IDC_m groups. The solid line represents the mean IDC spectrum minus the mean RMT spectrum, and the dotted line represents the mean IDC_m spectrum minus the mean IDC spectrum. Major absorbance–wavenumber differences are evident over virtually the entire spectral region, demonstrating that the progression from normal tissue to primary tumor tissue involves a markedly different suite of DNA modifications than the progression to the metastatic state.