Table I.
Activation of MAPKs in spinal glial cells after SNLa
MAPKs | Early phase (3 days) | Mid phase (10 days) | Late phase (21 days) |
---|---|---|---|
ERK | Microglia | Microglia/Astrocytes | Astrocytes |
p38 | Microglia | Microglia | Microglia |
JNK | Astrocytes | Astrocytes | Astrocytes |
Neuropathic pain is induced within 3 days (early phase), fully established at 10 days (mid phase) and maintained at 21 days (late phase).