. Author manuscript; available in PMC: 2008 Aug 1.

Published in final edited form as: Bioorg Med Chem. 2007 May 22;15(15):5198–5206. doi: 10.1016/j.bmc.2007.05.021

Table 2.

MAO Inhibitory Activity of Phenylisopropylamine Derivatives 1–4

Compound	Rat		Human
	K_i (μM)^a		K_i (μM)
	MAO-A	MAO-B	MAO-A	MAO-B
1	0.245 ± 0.030	>100	0.133 ±0.020	NE
2	0.054 ± 0.009	>100	0.075 ± 0.015	>100
3	0.115 ± 0.016	15.000 ± 1.430	0.030 ± 0.001	14.03 ± 1.082
4	0.392 ± 0.033	8.925 ± 1.575	0.022 ± 0.001	4.58 ± 0.850

K_i values for MAOs from rat brain were determined from the IC₅₀ values using the Cheng-Prusoff equation (see experimental section). NE: no effect at the highest concentration tested (100 μM).