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Variable sensitivity of CD8-depleted PBMC of HIV-infected individuals to the enhancing effect on HIV replication by neutralization of β-chemokines. CD8-depleted PBMC from five HIV-infected donors (154–885 CD4+ T cells/μl) were stimulated with anti-CD3 plus IL-2 and cultured in the presence of isotype control antibody or a combination of neutralizing anti-β-chemokine antibodies. Data represent peak HIV replication as measured by reverse transcriptase assay.
