Table 10.
Covariate variable derivations
| Variable | Definition |
| RV | Residual Volume by Spirometry and Plethysmography (TLC - Max (FVC or VC)) |
| TLC | Total Lung Capacity by Plethysmography |
| VC | Vital Capacity by Plethysmography |
| FVC | Forced Vital Capacity by Spirometry |
| FEV1 | Forced Expiratory Volume in the First Second by Spirometry |
| Target Lobe | RUL, RLL, LUL, or LLL |
| RUL | RUL Target vs. Others |
| Density Score | Density Score by Lobe |
| Total Density Score | Sum of all Lobar Density Scores (including RML) |
| Ipsilateral DS Heterogeneity | Target - Max DS of Non-treated Lobes within Treated Lung [e.g.: RUL - Max(RML, RLL)] |
| Thorax DS Heterogeneity | Target DS - Max DS of All Non-treated Lobes [e.g.: RUL - MAX (RML, RLL, LUL, LLL)] |
| Target Lobe DS % Delta | (TLC HRCT - RV HRCT)/TLC HRCT Density Score of Target Lobe |
| Target Lobe Volume % Delta | (TLC HRCT Volume - RV HRCT)/TLC HRCT Volume of Target Lobe |
| Fissure Score | Categorical Fissure Assessment Surrounding Target Lobe |
| 1 = Absent | |
| 2 = Incomplete | |
| 3 = Complete | |
| NETT Strata | 1 = Upper-Lobe Predominance, Low Baseline Exercise Capacity* |
| 2 = Upper-Lobe Predominance, High Baseline Exercise Capacity | |
| 3 = Non-Upper-Lobe Predominance, Low Baseline Exercise Capacity | |
| 4 = Non-Upper-Lobe Predominance, High Baseline Exercise Capacity | |
| Target Lobe Atelectasis Scores | % change in Target Lobe Volume at TLC and at RV between Baseline and 180-day HRCT |
| Lobar Exclusion | Yes, If all bronchial pathways to target lobe are sealed by valve(s) – adjudicated by HRCT Core Lab |
| Valve Combinations | 1. Small ONLY |
| 2. Small AND Large | |
| 3. Large Only | |
| Large Valve | Any procedure with Only Large Valves vs. all others |
| Small Valve | Any procedure with Only Small Valves vs. all others |
*Low Exercise Capacity by Cycle Ergometry ≤ 25 W for Women, ≤ 40 W for Men