Table 8.

Composite or other potential covariate interactions

Composite or Interactions	Definition
Baseline BODE	BMI, FEV1% predicted, MMRC, 6 MWT Composite Score
NETT Strata	Randomization Stratification by Baseline Cycle Ergometry and HRCT at TLC
NETT Strata by Right vs. Left	Randomization Stratification by Baseline Cycle Ergometry and HRCT at TLC, by Right or Left Lung
Lobar Exclusion by Fissure Interaction*	Fissure Score = 3 AND Lobar Exclusion = Yes vs. all others
Lobar Exclusion, Fissure, and RV % Predicted*	Lobar Exclusion = Yes AND Fissure Score = 3 AND RV % Predicted ≥ 200% vs. all others
Lobar Exclusion, Fissure, and RV % Predicted*	Lobar Exclusion = Yes AND Fissure Score = 3 AND RV % Predicted ≥ 200% vs. all others
Large Valve by Right vs. Left*	Right vs. Left Lung AND Large Only vs. Others
Small Valve by Right vs. Left*	Right vs. Left Lung AND Small Only vs. Others
Expectorated Valve Replaced*	Valve(s) Expectorated AND Lobar Exclusion = Yes vs. all others
Expectorated Valve Not Replaced*	Valve(s) Expectorated AND Lobar Exclusion = No vs. all others
Lobar Exclusion by Site*	Technical Success by Site
First Case by Site*	First Treatment Case by Site vs. All Others
Learning Curve by Site*	Experience Level: Case 1, vs. 2 & 3, vs. 4–6, vs. 7–9, vs. ≥10 by site.

*These potential covariates apply only to the treatment arm and do not have a control arm subset.