Figure 3.

Cytotoxicity of paclitaxel and CBDCA in HA-BAX versus neo-control clones. SW626 transfectants were seeded onto 24-well plates and exposed to a range of paclitaxel and CBDCA concentrations as indicated. Cells were trypsinized and counted on day 3 (A and B) or daily for 5 days (C). Percent survival was assessed by trypan blue exclusion and expressed as the percentage of viable cells present in the treatment group compared with cells grown in medium alone at the identical time point. For A and B, data are expressed as the mean ± SEM percent survival of HA-BAX clones A9, D7, and D8 and of neo-control clones A10, B10, and F8. Data obtained for C are derived by using HA-BAX clone A9 and neo-control clone A10 and represent results from two separate experiments.