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Effects of paclitaxel on the expression of BAX, BCL-2, and BCL-xL. Neo-control clone B10 was treated with paclitaxel (1.0 μM) for up to 48 hr, followed by immunoblot analysis as previously described. The dose of paclitaxel chosen for this experiment resulted in over 50% cytotoxicity of clone B10 at 48 hr of culture. There was no evidence of BCL-2 or BCL-xL down-regulation, or of BAX up-regulation, in the presence of paclitaxel.
