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. 2007 Aug 29;2(8):e804. doi: 10.1371/journal.pone.0000804

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Liu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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This figure showed the distributions for 3 groups of miRNA-mRNA pairs, classified by the distance between a miRNA and an mRNA on the same chromosome. The y-axis shows the percentage of miRNA-mRNA pairs in each range of correlation (−1 to 1 with binsize 0.1). An intronic miRNA had a distance zero to its host gene. The average length of a human gene, 55Kb (http://www.ncbi.nlm.nih.gov/Web/Newsltr/Spring03/human.html), was chosen as one distance boundary. As the distance between the correlated pair increased, the distribution increasingly shifted away from positive correlations to a normal distribution.