Fig. 2.

Comparison of rise time currents elicited by high GABA concentration between α1β2γ2 and α3β2γ2 channels. (A) Typical examples of normalized α1β2γ2- and α3β2γ2-mediated current responses to high GABA concentrations. Arrows point to responses to a distinct concentration for distinct subunit combinations. Note that whereas for α1β2γ2 10 mm GABA saturates the onset rate, in α3β2γ2-mediated responses onset saturation is achieved at 50 mm GABA. (B) Summary of data deriving for the assessment of the 10–90% rise time of current elicited at three distinct concentrations as indicated in at least four patches excised from human embryonic kidney cells expressing α1β2γ2 and α3β2γ2 receptors. *P < 0.05 indicates a significant difference between subunits.