Table 2.

Biodistribution in normal mice after an iv injection of [¹²⁵I]ligand (%ID/g, mean ± SD, n = 3 mice per group)

[125I]1 (LogP = 2.60)
Organ	2 min	30 min	1 hr	2 hr
Blood	4.23 ± 0.67	2.84 ± 0.32	3.19 ± 0.41	2.70 ± 0.09
Heart	15.8 ± 3.83	2.59 ± 0.68	1.53 ± 0.24	1.07 ± 0.03
Muscle	0.95 ± 0.27	1.43 ± 0.31	0.99 ± 0.20	0.67 ± 0.08
Lung	12.9 ± 3.20	4.00 ± 1.39	2.84 ± 0.43	2.07 ± 0.13
Kidney	16.3 ± 2.96	3.56 ± 0.82	2.78 ± 0.68	1.94 ± 0.10
Spleen	4.99 ± 0.21	1.76 ± 0.36	1.73 ± 0.34	1.46 ± 0.15
Liver	24.1 ± 4.06	11.2 ± 0.31	3.07 ± 0.62	1.76 ± 0.27
Skin	0.89 ± 0.07	2.12 ± 0.40	2.85 ± 0.23	2.75 ± 0.24
Brain	3.55 ± 0.91	3.10 ± 0.38	1.36 ± 0.10	0.33 ± 0.01
[125I]2 (LogP = 2.80)
Organ	2 min	30 min	1 hr	2 hr
Blood	3.45 ± 0.29	3.38 ± 0.51	2.71 ± 0.43	3.29 ± 0.61
Heart	13.0 ± 2.47	2.31 ± 0.37	1.41 ± 0.33	1.33 ± 0.26
Muscle	0.98 ± 0.30	1.23 ± 0.20	0.71 ± 0.09	0.78 ± 0.11
Lung	13.0 ± 2.32	4.03 ± 0.41	2.60 ± 0.56	2.77 ± 0.86
Kidney	16.6 ± 2.48	4.10 ± 0.54	2.85 ± 0.50	2.40 ± 0.47
Spleen	6.33 ± 1.03	1.98 ± 0.34	1.42 ± 0.40	1.73 ± 0.45
Liver	17.2 ± 2.86	11.2 ± 1.59	5.21 ± 2.05	2.24 ± 0.45
Skin	0.87 ± 0.14	2.22 ± 0.64	2.46 ± 0.27	3.18 ± 0.17
Brain	5.67 ± 1.49	4.51 ± 0.56	2.14 ± 0.21	0.91 ± 0.17