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. 2007 Jul 31;4(7):e237. doi: 10.1371/journal.pmed.0040237

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© 2007 Boucherat et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Developmental changes in control lungs were studied from 11 to 36 wk of pregnancy. Upper: representative Western blot. A 45-kDa band corresponds to NRG1-β1 (the 55-kDa band is nonspecific [61]). Lower: densitometric analysis (arbitrary units [a.U.]) in 15 individuals showing a significant linear increase (r = 0.75, p = 0.001).

(B) Comparative study in seven pairs of age-matched CDH (lanes labeled H) and control (lanes labeled C) lungs. Upper: representative Western blot. Lower: densitometric analysis; there was no significant difference in expression level between CDH and control lungs (p = 0.58).