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. Author manuscript; available in PMC: 2008 Jun 1.
Published in final edited form as: Exp Neurol. 2007 Feb 27;205(2):396–406. doi: 10.1016/j.expneurol.2007.02.009

Fig 1.

Fig 1

BBB related measures after SCI and treatment with vehicle, low dose (1mg/kg) or high dose (10mg/kg) of Pioglitazone. (A) Rats in each group recovered to a similar extent on the BBB scale. (B) Subscores were tallied for each category (see Table 1) and summed, which revealed that the high dose group attained significantly better total BBB subscores at 14d, 21d and 28d post-injury (dpi) compared to controls. (C) Significantly more rats in the high dose and low dose Pioglitazone groups recovered the ability to step by 14dpi compared to vehicle treated rats. (D) Both Pioglitazone groups displayed more frequent forelimb-hindlimb coordination than vehicle rats at 28dpi. (E) There was a trend for improved toe clearance over time in treated rats (Interaction X Treatment p<0.05). (F) Paw position subscores increased over time in all groups. At 14dpi, the high dose Pioglitazone group had a greater paw position subscore compared to vehicle controls due to more frequent parallel paw placements. All data are expressed as mean ± SEM. *p<0.05