Fig. 2. Initial marker rescue mapping of DL1-3.
A) Primer pairs used to construct PCR products for marker rescue. Products amplified using a library of primers are shown as bars above the region they amplify on a HindIII restriction map of the vaccinia virus genome. Each product is approximately 5 kb in length. The PCR product numbers shown here are used throughout our study. B) Confluent dishes of BSC40 cells were infected with the Dts38 helper virus and co-transfected with wild-type genomic DNA and the indicated PCR product. After a 4 day incubation at 37°C in the presence of IBT, dishes were stained with crystal violet.