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. Author manuscript; available in PMC: 2008 Aug 15.
Published in final edited form as: Virology. 2007 Apr 23;365(1):136–143. doi: 10.1016/j.virol.2007.03.032

Table 2.

PrPres distribution following oral infection of deer PrP+/+ tg mice with CWD braina

Sac. date Clinical signs Mouse # Non-neuronal tissues Neuronal tissues
Tongue Spleen Lung Liver Heart Intestine Olf. bulb Br. stem Cereb Cortex Hippo.
200–300 dpi No 1 ++ ++ nil nil nil ++ ++ ++ nil nil nil
No 2 ++ ++ nil nil nil ++ ++ ++ nil nil nil
No 3 ++ nil nil nil nil nil nil nil nil nil nil
350–410 dpi Yes 1 ++ ++ nil nil nil ++ ++ ++ ++ ++ ++
Yes 2 ++ ++ nil nil nil ++ ++ ++ ++ ++ ++
Yes 3 ++ ++ nil nil nil ++ ++ ++ ++ ++ ++
a

Mice were inoculated orally with a 5% brain homogenate stock made from mule deer dying of CWD. Neural and non-neural tissues were isolated and stored in 4% paraformaldehyde and processed for immunohistochemistry.