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. Author manuscript; available in PMC: 2007 Aug 21.
Published in final edited form as: J Immunol. 1991 May 1;146(9):3227–3234.

Figure 3.

Figure 3

In vivo growth of unmodified and gene modified tumor cells. B6 animals were injected s.c. with 1 × 107 neo-transfected (NEO) , TNF-transduced (TNF-B).or unmodified WP-4 tumor cells on day 0 and tumor growth was followed over time. Unmodified and neo-transfected WP-4 tumors grew progressively over time and no regressions were observed. In contrast, bulk TNF-transduced tumor cells typically grew progressively over an 8- to 12-day period at which point approximately 70% regressed completely. In the representative experiment shown here, 91% of the TNF-transduced tumors regressed. (* number with tumor/total at day 28. Tumor area measurements are plotted for each time point and are expressed as mean ± SEM.)