Figure 4.

Growth of TNF producing tumor clones in mice. Two consecutive experiments in which the in vivo growth of different TNF-producing clones was assessed. On day 0, B6 mice received 1 × 10⁷ tumor cells s.c. and tumor growth was followed over time. In both experiments, low TNF-producing clones (TNF-2 and TNF-28) grew progressively in all but one animal. In contrast, animals bearing high TNF producing tumors (TNF-12. TNF-26) experienced significant reductions in average tumor size after an initial period of tumor growth, and several animals experienced complete tumor regression. (^* number with tumor/total at day 28, Tumor area measurements are plotted for each time point and are shown mean ± SEM.)