Table 1.
Characteristics of patients with excessive bleeding vs those withouta
| Variables | < 1000 cc (n = 13) | > 1000 cc (n = 13) | P |
| Demographic | |||
| Sex (% males) | 6 (46) | 9 (69) | 0.21 |
| Age (years) | 69 (60–75) | 64 (61–75) | 0.88 |
| Body Mass Index (BMI) (kg/m2) | 29.3 (28–32) | 26.1 (25–27.9) | 0.03 |
| APACHE-II | 13 (11–16) | 14 (12–18) | 0.21 |
| SAPS-II | 31 (31–32) | 31.5 (29–40) | 0.78 |
| Parsonnet | 17.5 (13.5–21) | 15(9–20.5) | 0.55 |
| Surgical parameters | |||
| Type of bypass (%) | 0.03 | ||
| Venous | 4 (31) | 0 | |
| Arterial and venous | 8 (61.5) | 4 (31) | |
| Cardiopulmonary bypass time (min) | 85 (77–110) | 100 (67–110) | 0.84 |
| Aortic clamping time (min) | 63 (45–71) | 55 (50–70) | 0.96 |
| Temperature during CPB (°C) | 32 (31.5–32) | 31 (30–32) | 0.04 |
| Laboratory parameters | |||
| C1q 0 h (mg/ml) | 10.4(8.7–16.5) | 6.9 (6.2–9.1) | 0.02 |
| C1q 4 h (mg/ml) | 14.9 (9.3–16) | 7.6 (7.1–9.8) | <0.01 |
| C1q 24 h (mg/ml) | 12.8 (9.9–15.6) | 8.4 (7.2–10.1) | 0.04 |
| C1-Inhibitor 0 h (mg/ml) | 20.4 (16.6–21.4) | 13.2 (10.4–16.8) | 0.03 |
| C1-Inhibitor 4 h (mg/ml) | 19.5 (16.2–20.5) | 13.2 (10.8–17) | 0.04 |
| C4 24 h (mg/ml) | 21.2 (17–22.5) | 14.7 (13.8–18.8) | 0.04 |
| C3 4 h (mg/ml) | 87 (76–94) | 85(70–88) | 0.01 |
| B Factor 0 h (mg/ml) | 21.4 (18.9–26.4) | 15.6 (15.3–20.2) | 0.03 |
| B Factor 4 h (mg/ml) | 24.7 (18.7–28.2) | 18.6 (17–19.7) | 0.02 |
| C7 0 h (mg/ml) | 6.3(5.4–8.5) | 3.3 (2.5–5.9) | <0.01 |
| C7 4 h (mg/ml) | 6.6 (5–9.6) | 3.3 (2.1–4.6) | <0.01 |
| Leptin 0 h (ng/ml) | 12.1 (7.5–22.4) | 5.5 (1.9–7.7) | 0.01 |
| Leptin 4 h (ng/ml) | 10.7 (7.8–19.2) | 4.2 (1.4–6.2) | <0.01 |
| Leptin 24 h (ng/ml) | 32.6 (20.4–48.1) | 6.9 (3.8–12.3) | <0.01 |
| Prothrombin time admission (%) | 77 (72–79) | 70 (56–71) | 0.04 |
| Prothrombin time 4 h (%) | 77 (68–81) | 67 (64–69) | 0.03 |
| Fibrinogen 4 h (mg/ml) | 351 (272–409) | 272 (209–319) | 0.03 |
| Plasminogen activator inhibitor-1 preoperative (ng/ml) | 43.5 (31.5–52.8) | 25.5 (23–36) | 0.01 |
| Plasminogen activator inhibitor-1 0 h (ng/ml) | 76.6(53.5–97.3) | 35.5 (32.1–42.6) | <0.01 |
| PAI-1/t-PA ratio 0 h | 3.7 (2.7–6.8) | 1.6 (1.2–3.4) | 0.014 |
| Hematocrit (%) 4 h | 28.6 (25.8–31.9) | 25.4 (24–27.8) | 0.048 |
| Total red blood cells (ml) | 400 (0–800) | 1600 (800–2000) | <0.01 |
| Total plasma frozen (ml) | 0 | 800 (0–900) | 0.047 |
| Blood loss 4 h (mL) | 661 (572–992) | 220 (170–520) | 0.01 |
| Blood loss 24 h (mL) | 1190 (978–1762) | 605 (470–1100) | 0.01 |
aValues are expressed as median and ranges.