Table 1.

Significant coefficients generated by fitting the SERD equation to the survival curves shown in Figures 1, 2 and 3.

Cell line	Parameter	Value (± standard error)	p-value*
CHO-K1 (Fig 1a)	α	0.142 (± 0.021)	<0.0001
	β	0.043 (± 0.005)	<0.0001
	δz	-0.133 (± 0.023)	<0.0001
	δα	0.112 (± 0.015)	<0.0001
	δG	34.649 (± 12.328)	0.005
	δdC	0.037 (± 0.008)	<0.0001
V79-379A (Fig 1b)	α	0.187 (± 0.019)	<0.0001
	β	0.016 (± 0.004)	0.0003
	G	2.235 (± 0.666)	0.0009
	dC	0.161 (± 0.031)	<0.0001
	δz	-0.184 (± 0.017)	<0.0001
T98G exponential phase (Fig 2a)	α	0.208 (± 0.006)	<0.0001
	δz	-0.101 (± 0.014)	<0.0001
	δG	10.116 (± 10.374)	0.330
	δG	7.81	0.020
	δdC	0.033 (± 0.019)	0.076
	δβ	0.013 (± 0.002)	<0.0001
T98G growth-arrested (Fig 2b)	α	0.175 (± 0.003)	<0.0001
	δz	0.051 (± 0.007)	<0.0001
	δα	-0.017 (± 0.005)	0.0005
U373-MG exponential phase (Fig 3a)	α	0.270 (± 0.011)	<0.0001
	δz	0.068 (± 0.021)	0.002
	δβ	0.028 (± 0.004)	<0.0001
U373-MG growth-arrested (Fig 3b)	α	0.126 (± 0.014)	<0.0001
	β	0.031 (± 0.003)	<0.0001
	δz	-0.044 (± 0.012)	0.0002

* Log-likelihood ratio test (L-ratio) was applied to include or drop parameters from the final equation. p-values shown were derived from a t-test that the parameter is zero. The L-ratio and associated p-value is shown only when the tests did not agree (i.e. significance in one but not the other).